The effect of hydro-ethanolic extract of Curcuma longa rhizome and curcumin on total and differential WBC and serum oxidant, antioxidant biomarkers in rat model of asthma

Authors

  • Farzaneh Shakeri Neurogeneeic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran|Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  • Mohammad Hossein Boskabady Neurogeneeic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran|Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  • Mohammad Soukhtanloo Department of Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Abstract:

Objective(s): The effects of Curcuma longa (C. longa) and curcumin on total and differential WBC count and oxidant, antioxidant biomarkers, in rat model of asthma were evaluated. Materials and Methods: Total and differential WBC count in the blood, NO2, NO3, MDA, SOD, CAT and thiol levels in serum were examined in control, asthma, Asthmatic rats treated with C. longa (0.75, 1.50, and 3.00 mg/ml), curcumin (0.15, 0.30, and 0.60 mg/ml), and dexamethasone (1.25 μg/ml) rats. Results: Total and most differential WBC count, NO2, NO3 and MDA were increased but lymphocytes, SOD, CAT and thiol were decreased in asthmatic animals compared to controls (P

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Journal title

volume 20  issue 2

pages  155- 165

publication date 2017-02-01

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