The Effect of 12 Weeks Combined Training and Caffeine on Plasma Levels of Interleukin-1 Beta and Interleukin 10 in Obese Men

Aims Physical inactivity is associated with low-grade systemic inflammation and thus increased risk of chronic disease. Beneficial effects of caffeine on adipocytes metabolism and its anti-inflammatory properties have been reported. The aim of this study was to evaluate the effect of 12 weeks combined training and caffeine on plasma levels of inflammatory and anti-inflammatory markers in obese men. Methods & Materials In a semi-experimental trial, 44 obese men were purposefully and accessibly selected and into four groups: 1) control (n=11), 2) combined training (n=11), 3) caffeine (n=11) and 4) combined training -caffeine (n=11). Subjects received 6 mg of caffeine per kilogram of body weight daily for 12 weeks. The combined training program was performed for 12 weeks and 3 sessions per week. plasma levels of inflammatory (interleukin-1 beta (IL-1β) and anti-inflammatory (interleukin-10 (IL-10) markers were measured using ELISA kit. Data were analyzed by dependent t-test, one-way ANOVA and Tukey post hoc test at the p<0.05. Findings The results showed that 12 weeks of combination training, caffeine and combined training - caffeine significantly reduced IL-1β levels and increased IL-10 in obese men at posttest compared to the pretest (p=0.001). Also, changes in IL-1β and IL-10 levels were more in the combined training - caffeine group (p=0.001). Conclusion According to the results, it seems that combined training with caffeine has positive effect on body composition and improves inflammatory and anti-inflammatory markers in obese people.