The effect of 12 weeks aerobic exercise on DHEAso4, 17OH-Progestron concentrations, number of follicles and menstrual condition of women with PCOS

Introduction: The effective method of treatment of Polycystic Overy Syndrome (PCOS) is lifestyle modification. The aim of this study was to evaluate the effect of 12 weeks aerobic exercise on DHEAso4, 17OH-Progestron Concentrations, number of follicles and menstrual condition of women with PCOS. Methods: In this clinical trial, 40 PCOS patients lean (BMI<20) and obese (BMI>25) randomly divided into two trained and sedentary control groups. DHEAso4, 17OH-Progestron Concentrations, number of follicles and menstrual condition were measured before and after the program (12-week exercise training program, aerobic exercise at 60-80% of maximal heart rate, 25-30 min/day, 3 days/week). Results: Decline of DHEAso4, 17OH-Progestron Concentrations were significant after exercise in obese group (P=0.023, P<0.0001). The number of follicles right and left ovaries decreased significantly after exercise in two groups lean and obese (Right P=0.019, P=0.041 and Left ovary P=0.005, P=0.008). Menstrual situation was improved after exercise in obese and lean groups (P=0.028, P<0.0001). The body weight decreased significantly after exercise in obese groups (P<0.0001). Conclusion: It seems that a term of exercise with weight loss can induce decline of DHEAso4 and 17OH-Progestron. In addition, exercise lead to improved menstrual condition and reduction of number of ovarian follicles per groups of lean and obese.