The Chemoselective Fischer’s Synthesis of Indolenine Derivatives By iso-Butyric Acid As A Weak Organic Acid Catalyst

Authors

Hadi Jabbari Department of Chemistry, Payame Noor University, PO BOX19395-469 Tehran, Islamic Republic of Iran

Issa Amini Department of Chemistry, Payame Noor University, PO BOX19395-469 Tehran, Islamic Republic of Iran

Omidali Pouralimardan Department of Chemistry, Payame Noor University, PO BOX19395-469 Tehran, Islamic Republic of Iran

sami sajjadifar Department of Chemistry, Payame Noor University, PO BOX19395-469 Tehran, Islamic Republic of Iran

Z. Navabi Department of Chemistry, Payame Noor University, PO BOX19395-469 Tehran, Islamic Republic of Iran

Abstract:

Iso-butyric acid as a new, simple, and expensive solvent/catalyst was successfully used for the chemoselective Fischer’s synthesis of indolenines derivatives 3a-r by one-pot condensation reaction of various phenylhydrazines 1a-e with the substituted acetophenones 2a-c at reflux conditions. In this protocol, all products 3a-r were obtained in high yields and short reaction time. The structures of the product were established with spectroscopic data of 1H NMR, 13C-NMR, and FT-IR.

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Journal title

Journal of Sciences Islamic Republic of Iran

volume 30 issue 2

pages 129- 134

publication date 2019-04-01

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Keywords

Fischer’s synthesis Indolenines 3H-Indole Phenylhydrazine Iso-butyric acid

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