The Assessment of Toxicity Characteristics of Cellular Uptake of Paramagnetic Nanoparticles as a New Magnetic Resonance Imaging Contrast Agent

Authors

  • Hamidreza Moghimi Department of Pharmaceutics and Pharmaceutical Nanotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Nader Riahialam Department of Medical Physics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
  • Reza Zohdiaghdam Departmentof Medical Imaging, School of ParaMedicine, Urmia University of Medical Sciences, Urmia, Iran.
  • Zhaleh Behrouzkia Department of Medical Physics, School of Medicine, Urmia University of Medical Science, Urmia, Iran.
Abstract:

Nanoparticles are unique that enable many promising medical and technological applications intheir physical, and chemical properties. It is widely accepted that nanoparticles should bethoroughly tested for health nanotoxicity, but a moderate risk analysis is currently prevented by arevealing absence of mechanistic knowledge of nanoparticle toxicity. The purpose of this studywas to assess in-vitro cytotoxicity of Gadolinium oxide with diethylene glycol polymer (Gd2O3-DEG) and magneto liposome nanoparticles (MLNs) in Hepa 1-6 cell lines as models to assessnanotoxicity in-vitro. The effects of magnetic nanoparticles on these cell lines were evaluated by2light microscopy and standard cytotoxicity assays. The underlying interactions of thesenanoparticles with physiological fluids are key characteristics of the perception of their biologicalefficacy, and these interactions can perhaps be performed to relieve unpleasant toxic effects.Ourresults demonstrated that the Gd2O3-DEG and MLNs had significantlydifferent non-cytotoxiceffects. Our results suggest that these cell lines provide valuable models to assess the cytotoxicityof nanoparticles in-vitro. The results of the present study demonstrated that MLNs and Gd2O3-DEG with lower longitudinal relaxation time (T1) than Gadolinium Pentetic acid (Gd-DTPA) inHepa 1-6 cell lines are sensitive positive Magnetic Resonance Imaging (MRI) contrast agents thatcould be as attractive as candidates for cellular and molecular lipid content targets such as liverdiagnostic applications. These data reveal that MLNs is a useful positive contrast agent fortargeting and cell tracking. This will help to image of cells and special organs like liver that uptakesliposomal formulation very well.

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Journal title

volume 18  issue 4

pages  2083- 2092

publication date 2019-12-01

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