The Affect of Ginger on the Severity of Nausea and Vomiting induced by ‎Chemotherapy in Cancer' Patient Referred to Razi Hospital in Rasht ‎‏2007-2008‏

Introduction: nausea and vomiting caused by chemotherapy is the most important ‎complication and discomfort for cancer patients. Nausea and vomiting causes physiologic and ‎electrolyte disorders, Immunity system changes, Nutrition disorders and rupture of esophagus ‎and effect in the quality of life and continuing of patient's treatment. Ginger is one vegetable ‎and effective drug for the treatment of nausea and vomiting and doesn’t have any special side ‎effects and some countries use it for producing of antiemetic drugs.‎ Objective: This study aims to determine the affection of ginger on the severity chemotherapy ‎‎–induced nausea and vomiting of cancer patients.‎ Methods: This study is a randomized, cross-over, double – blinded, similarization clinical trial, ‎done on ‎‏44‏‎ cancer patients undergoing chemotherapy. In the first cycle of the study, Patients ‎randomly assigned by four block random allocation to receive one of the antiemetic regimen ‎‎(regimen A (routine + ‎‏1‏‎ gr ginger) and regimen B (routine ‎‏+1‏gr Placebos). In the next cycle of ‎chemotherapy, ‎‏28‏‎ days after the previous cycle another regimen (A or B) administrated ‎together with chemotherapy drugs. The severity of the nausea and vomiting were measured in ‎‏4‏h (‎‏1‏‎, ‎‏2‏‎, ‎‏3‏‎, ‎‏4‏‎(hours)) after second dose and at the end of the ‎‏24‏h after receiving first dose by ‎using of VAS and kortila tools.‎ Results: Finding indicated that on totally , we didn't achieve any difference on number of ‎nausea and vomiting on two treatment regimens .But on the different hours, findings showed ‎decrease of nausea and vomiting on ginger group patients ‎ Conclusion: According to achieved finding, Researcher believed that no significant ‎difference between treatment regimens might be related to low sample size, time prescribtion ‎of ginger different kind cancer and different dose of ginger ‎