SYNTHESIS OF NEW PHASE- 1 METABOLITES OF TWO BARBITURATES
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Abstract:
The new 4'- hydroxy and 3'- aldehyde phase- 1 metabolites of butobarbitone and pentobarbitone are fully synthesized for the first time. These metabolites were used to idenfity and quantify the natural metabolites in human urine after single and multiple doses of these drugs. The synthesized metobolites have spectral characterizations (IR, NMR, U.V. and mass spectroscopy) consisted with the assigned structures
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Journal title
volume 1 issue 5
pages -
publication date 1990-11-01
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