Surveying The Variations of Lipid and Lipoprotein-Cholesterol in Acute Lymphoblastic Leukemia
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Abstract:
The importance of variations in lipid and lipoprotein-cholesterol level has been determined in many disorders including cardiovascular and metabolic ones. The following study has been achieved with the aim of determining the level of these factors and their standard variation criteria in patients with acute lymphoblastic leukemia (ALL). To meet this demand, serum lipid and lipoprotein-cholesterol were assessed in 42 patients with ALL, divided in two groups of children (under 15 years) and adults (over 15 years), in a two phase study: 1- before therapy, 2- after the first course of chemotherapy. Precipitation method and applying the acetate cellulose electrophoresis were our methods of choice. Results have shown a significant increase in TG and VLDL-C level in patients (before therapy) in comparison with the control group (112.7 to 142.2 mg/dl and 22.5 to 28.5 mg/dl, respectively), in the meantime, a significant decrease has been noted in HDL-C level (32.3 to 21.5 mg/dl). In patients with complete remission, the results have revealed significantly decrease in TG and VLDL-C levels after inducing chemotherapy (142.9 to 121mg/dl and 28.6 to 24.2 mg/dl), whereas significantly increase was determined in HDL-C level (22.0 to 29.8).
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Journal title
volume 24 issue None
pages 7- 14
publication date 2000-03
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