Stability ‎a‎nalysis of the transmission dynamics of an HBV model

Authors

  • A. A. Heydari Research Center for Infection Control and Hand ‎Hygiene, Mashhad University Of Medical Sciences, Mashhad, Iran.
  • A. Heydari Department of Mathematical Sciences‎, ‎Payame Noor University‎,‎ P. O. Box 19395-3697‎, ‎Tehran‎,‎ Iran‎.
  • A. Vahidian Kamyad Department of Mathematics Sciences‎ , ‎University of Ferdowsi‎, ‎Mashhad‎, ‎Iran‎.
  • R. Akbari Department of Mathematical Sciences‎, ‎Payame Noor University‎ ,‎P.O.Box 19395-3697‎ , ‎Tehran‎ ,‎Iran.
Abstract:

‎Hepatitis B virus (HBV) infection is a major public health problem in the world today‎. ‎A mathematical model is formulated to describe the spread of hepatitis B‎, ‎which can be controlled by vaccination as well as treatment‎. ‎We study the dynamical behavior of the system with fixed control for both vaccination and treatment‎. ‎The results shows that the dynamics of the model is completely determined by the basic reproductive number R_0. ‎if R_01, ‎the disease-free equilibrium is unstable and the disease is uniformly persistent‎. ‎Furthermore‎, ‎If R_0>1, ‎the unique endemic equilibrium is globally asymptotically stable by using a generalization of the Poincar e-Bendixson ‎criterion.‎

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stability ‎a‎nalysis of the transmission dynamics of an hbv model

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Journal title

volume 8  issue 2

pages  119- 129

publication date 2016-04-01

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