Solubility of Naproxen in Polyethylene Glycol 200 + Water Mixtures at Various Temperatures

Authors

  • Fleming Martinze Grupo de Investigaciones Farmacéutico-Fisicoquímicas, Departamento de Farmacia, Universidad Nacional de Colombia, A.A. 14490, Bogotá D.C., Colombia
  • Shahla Soltanpour Faculty of Pharmacy, Zanjan University of Medical Sciences, Zanjan 45139, Iran
  • Vahid Panahi-Azar Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Abstract:

The solubility of naproxen in binary mixtures of polyethylene glycol 200 (PEG 200) + water at the temperature range from 298.0 K to 318.0 K were reported. The combinations of Jouyban-Acree model + van’t Hoff and Jouyban-Acree model + partial solubility parameters were used to predict the solubility of naproxen in PEG 200 + water mixtures at different temperatures. Combination of Jouyban-Acree model with van’t Hoff equation can be used to predict solubility in PEG 200 + water with only four solubility data in mono-solvents. Theobtained solubility calculation errors vary from ~ 17 % up to 35 % depend on the number of required input data.Non-linear enthalpy-entropy compensation was found for naproxen in the investigated solvent system and the Jouyban−Acree model provides reasonably accurate mathematical descriptions of the thermodynamic data of naproxen in the investigated binary solvent systems.

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Journal title

volume 14  issue 4

pages  1041- 1050

publication date 2015-10-01

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