Salvianolic Acid Improves Status Epilepticus and Learning and Memory Deficiency in Rat Model of Temporal Lobe Epilepsy
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Abstract:
Background and Objective: Epilepsy is a long-lasting central nervous system disorder that is accompany with spontaneous seizures and insufficiency in learning and memory. Now drug treatment is the most common therapy but some patients do not research to suitable control of their seizures with current drugs. Hence, new treatment is needed to help those patients that are unaffected to existing drugs. In present study, we evaluate the protective effect of pretreatment with salvianolic acid B in experimental model of temporal lobe epilepsy in male rats. Materials & Methods: In the present study, the effect of intraperitoneal administration of salvianolic acid B (10 mg/kg) on induced seizures and learning and memory impairment induced by intrahippocampal injection of kainic acid (KA, 4 mg) were assessed in rats. Results: Obtained data showed that the epileptic rats display kainic acid-induced seizures. On the other hand, in epileptic rats, spontaneous alternation score in Y maze tasks lowered (p
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Journal title
volume 3 issue 1
pages 39- 46
publication date 2015-03-03
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