Polymorphisms in the Apolipoprotein E Region and Severity of Multiple Sclerosis

Authors

  • D.D. Farhud National Research Center for Genetic Engineering and Biotechnology, Tehran University of Medical Sciences, Tehran, Iran.
  • M. Hushmand National Research Center for Genetic Engineering and Biotechnology, Tehran University of Medical Sciences, Tehran, Iran.
  • M. Seyedian Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • M. Younesian Dept. of Environmental Health Engineering , School of Public Health & Institute of Public Health Research, Tehran University of Medical Sciences, Tehran, Iran.
  • M.H. Sanati National Research Center for Genetic Engineering and Biotechnology, Tehran University of Medical Sciences, Tehran, Iran.
  • S.M. Nabavi Shahed Medical University, Depart-ment of Neurology, Tehran University of Medical Sciences, Tehran, Iran.
  • V. Hadavi Dept. of Human Genetics & Anthropology, School of Public Health & Institute of Public Health Research, Tehran University of Medi-cal Sciences, Tehran, Iran
Abstract:

Background: The apolipoprotein E (APOE) polymorphism is known to affect various neurologic disorders with different effects on the immune system and CNS repair. However, previous studies on possible modulation of the clinical course of multiple sclerosis (MS) by APOE polymorphism have been inconsistent. Objective: To clarify the issue for MS patients' management and future research. Methods: The present cross-sectional study investigated 81 patients with clinically proven MS and related their clinical and demographic findings to the allelic polymorphism of the APOE gene. The genotype distribution of patients with MS was compared with a comparison group of 93 asymptomatic elderly volunteers. Results: Significant differences were found in the distribution of e4 allele between patients with MS and the comparison group (9.3% vs. 0.5%; p<0.001). An analysis of disease progression in 81 patients with MS indicated that APOE e4 carriers are more likely to be affected with severe disease. Conclusion: The results obtained suggested that APOE genotype affected susceptibility to MS and indicated an association of the APOE e4 allele with a more severe course of the disease. 

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

polymorphisms in the apolipoprotein e region and severity of multiple sclerosis

background: the apolipoprotein e (apoe) polymorphism is known to affect various neurologic disorders with different effects on the immune system and cns repair. however, previous studies on possible modulation of the clinical course of multiple sclerosis (ms) by apoe polymorphism have been inconsistent.   objective: to clarify the issue for ms patients' management and future research.   methods...

full text

Association of Apolipoprotein E Polymorphism with Susceptibility to Multiple Sclerosis

full text

AN INVESTIGATION OF HUMAN APOLIPOPROTEIN E POLYMORPIDSMS IN MULTIPLE SCLEROSIS PATIENTS OF IRAN

Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system, with a complex etiology that includes a strong genetic component. The chromosome 19q 13 region surrounding the apolipoprotein E (APOE) gene has shown consistent evidence of involvement in MS. In a cross-sectional study, to show the APOE genotype and allele frequency in the MS population of Iran in comp...

full text

the u.s. policy in central asia and its impact on the colored revolutions in the region (the case study of tulip revolution in kyrgyzstan)

چکیده ندارد.

15 صفحه اول

the study of aaag repeat polymorphism in promoter of errg gene and its association with the risk of breast cancer in isfahan region

چکیده: سرطان پستان دومین عامل مرگ مرتبط با سرطان در خانم ها است. از آنجا که سرطان پستان یک تومور وابسته به هورمون است، می تواند توسط وضعیت هورمون های استروئیدی شامل استروژن و پروژسترون تنظیم شود. استروژن نقش مهمی در توسعه و پیشرفت سرطان پستان ایفا می کند و تاثیر خود را روی بیان ژن های هدف از طریق گیرنده های استروژن اعمال می کند. اما گروه دیگری از گیرنده های هسته ای به نام گیرنده های مرتبط به ا...

15 صفحه اول

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 29  issue 2

pages  67- 71

publication date 2015-10-03

{@ msg @}

By following a journal you will be notified via email when a new issue of this journal is published.

Keywords

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023