P-7: Association of Gonad Failure with SerumInsulin Level
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Abstract:
Background: Serum insulin variations are occasionally observed in patients suffering infertility or gonad failure. The main purpose of the present study was to clarify the effects of gonadectomy and sex steroid hormone replacement on serum insulin level in rats. Materials and Methods: Male rats were divided into control, orchidectomized, and testosterone receiving orchidectomized animals. Female rats were also divided into control, ovariectomized, progesterone or estradiol receiving ovariectomized animals. Testosterone (50mg/kg/day) or progesterone (20 mg/kg/day) and estradiol (200μg/kg/ day) were injected intraperitineally or subcutaneously, respectively. The period of 4 weeks was considered for each experiment. After 4 weeks, serum insulin was measured and compared statistically between the groups (ANOVA). Results: In male rats, orchidectomy caused to decreasing (p
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Journal title
volume 4 issue 2
pages -
publication date 2010-05-01
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