P-51: Potential Benefits of The Treatment of Leucocytospermia on The Improvement of Semen Quality and Fertility in Male Partners if Infertile Couples

Background: To analyze the evolution of semen parameters in leucospermic men explored for a couple&#039;s infertility according to the therapeutic management of leucocytospermia. The potential benefits of leucocytospermia treatment on the natural pregnancy outcomes are also examined. Materials and Methods: Our study was carried out in 100 leucospermic male parteners of infertile couples. Leucocytospermia was routinely determined using the peroxidase technique and defined as the presence of more than 1 × 106 leucocytes per milliliter of semen in the first ejaculation according to WHO guidelines. The evolution of leucospermia was controlled by repetitive semen analysis with at least three months intervals. We excluded leucospermic men with bacterial sperm infection. All clinical and paraclinical exploration data of the couple were listed. We assess the evolution of different semen parameters and the couple’s fertility according to the therapeutic management of leucocytospermia. Results: The most frequent semen abnormalities in the first ejaculation were asthenospermia and teratospermia (62 and 74% of patients, respectively). Antibiotherapy was prescribed in 79% of patients and 21% of patients did not receive any treatment. An antiinflammatory therapy and different vitamins and antioxidative drugs were associated with antibiotics in 63.2 and 88.6% of treated patients respectively. A total regression of leucocytospermia was observed in 49% of treated patient group. We also noted a disappearance of leucocytospermia in 38% of no treated patients (p< 0.001). The aggravation of leucocytospermia was significantly higher in no treated patients (52 % versus 10 % in treated group, p<0.001). However, the rates of semen parameters improvement associated to regression of leucocytospermia among the treatment group was significantly greater than that of no treatment group (25% vs. 5 % respectively, p = 0.002). In the treated group, we noted the occurrence of spontaneous pregnancy in 25 couples (32%). No pregnancy was observed in the group of no treated patients. Conclusion: leucocytospermia might have deleterious effects on male fertility. Etiological diagnostic approach must be proceeded to guide the optimum therapeutic management. Antibiotic therapy for such a condition could improve semen parameters and restore the natural fertility among infertile couples.