P-32: Histomorphological Study of Testicular Seminiferous Tubules Following Time Dependent Administration of Methylphenidate in Adult Rats

Authors

  • Kianifard D
Abstract:

Background: Methylphenidate (MPH), Ritalin, is one of the most common medications. The administration of Ritalin leads to increase of the activity of central nervous system. Ritalin may be used for maintaining alertness and improving of attention which may lead to increase of the risk of substance abuse in some cases. There is a little data about the effects of long term treatment with Methylphenidate on body organs involved in fertility ability. Regarding to the effect of normal fertility on the physical and mental health of males, this study was designed to investigate the time dependent effects of MPH on the activity of male reproductive system. Materials and Methods: Ritalin was administrated to adult rats (10 mg/kg/day) in three experimental groups for periods of two weeks, 11 weeks and 11 weeks with one week interval between each two weeks. At the end of investigation, Histological studies were performed for evaluation of testicular reproductive function. Results: Histological assessment of testicular tissue showed some alteration in morphology of spermatogenic cells of seminiferous tubules. These changes were disruption of spermatogenesis, decrease of the diameter of seminiferous tubules, depletion in the height of germinal epithelium, giant cell formation and the alteration of the shape of testicular tubules. Most of these changes were observed in long term treated group in comparison to other groups. Conclusion: The findings of this study indicate that, the long term use of methylphenidate can adversely damage the male fertility due to impairment of normal spermatogenesis.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

P-32: Histological Study of Cauda Epididymis in Adult Rats Treated with Methylphenidate

Background: Methylphenidate commonly known as Ritalin is one of the most common medications. The administration of Ritalin leads to increase of the activity of central nervous system. Because of this property, Ritalin may be used for maintaining alertness and improving of attention which may lead to increase of the risk of substance abuse in some cases. There is a little data about the effects ...

full text

P-4: Effect of Chronic Stress on Stereological Properties of Seminiferous Tubules in Adult Male Rats

Background Male fertility and reproduction can affect by stress. The means by which stress influences reproduction is not clearly understood. The aim of the present study was to examine, using stereological methods, the role of glucocorticoids during chronic restraint stress on spermatogenesis. MaterialsAndMethods Twenty four male adult Sprague- Dawley rats were allocated to four equal groups; ...

full text

P-98: Ultrastructural Study of Basement Membrane of Seminiferous Tubules in Adult Diabetic Rats with Spermatogenic Alterations

Background: The complications of diabetes are the major problems that occur in diabetic patients. It has been reported that, insulin insufficiency and the impairment of regulatory action of this hormone on Leydig and Sertoli cells have an important role in testicular alterations. Testicular disorders and change in normal spermatogenesis is one of the consequences of diabetes. This study was des...

full text

P-33: Epididymal Sperm Analysis afterTime Dependant Administration of Methylphenidate in Adult Male Rats

Background: Methylphenidate is one of the most common medications used for treatment of attention-deficit/hyperactivity disorder. It may be used for maintaining alertness and improving of attention which may lead to increase of the risk of substance abuse in some cases. The occurrence of alteration in male reproductive system such as hormonal secretion changes and alteration of testicular sperm...

full text

Effect of Syzygium aromaticum (clove) extract on seminiferous tubules and oxidative stress after testicular torsion in adult rats

Introduction: The aim was to investigate the protective effect of the Syzygium aromaticum extract on damaged tissues and the oxidative stress after testicular torsion. Methods: Rats were randomly divided into a control group subjected to a sham procedure and three treatment groups comprising testicular torsion followed by detorsion (TD), testicular torsion detorsion followed by the tre...

full text

P-36: Morphometric Evaluation of Seminiferous Tubules in Aged Mice Testes after Melatonin Administration

Background: Melatonin, the pineal gland hormone as a direct or indirect antioxidant and free radical scavenger, is involved in the process of both aging and age-related diseases. This study investigates the effects of melatonin on the histology of testicular seminiferous tubules in aged mice. Materials and Methods: Twenty male, white mice, aged 16 months, that weighed 20-23 gr were equally divi...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 7  issue 3

pages  48- 48

publication date 2013-09-01

By following a journal you will be notified via email when a new issue of this journal is published.

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023