P-184: The Role of Cell Surface Toll Like Receptors in Endometriosis
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Abstract:
Background: Toll like receptors (TLRs) are a major family of innate immune systems which recognize specific pathogen associated molecular patterns (PAMPS)in bacterial, fungi, virus and parasites. Human TLRs comprise a large family of 10 different type proteins that are expressed on various immune cells. Among these receptors, TLR1, 2, 4, 5, 6 and 10 were expressed on the cell surface. TLR2 forms heterodimers with TLR1 or TLR6 which recognize bacterial lipoproteins and lipopeptides, TLR4 that recognizes lipopolysaccharides (LPS) and TLR5 that recognizes flagellin. TLR10 is highly homologous to TLR2, but its function is still unknown and no specific ligand has been yet identified. Endometriosis is a benign gynecologic disorder characterized by the ectopic growth of misplaced endometrial cells. Endometriosis is involved mainly innate immune System. Whereas TLRs are expressed in the endometrial cells as a result their expression and their regulation might be vital for the pathogenesis of endometrial diseases especially endometriosis. Materials and Methods: This study contains three groups (n=5). Ectopic biopsies were obtained with laparoscopic procedure from patient with endometriosis. Eutopic and control biopsies were gained with piplle from endometrium of women with and without endometriosis. The existence of TLR1,2,4,5,6 and 10 genes were tested with RT-PCR and Q-PCR has shown different levels of genes expression in this test. Results: TLR1, 2, 4, 5, 6 and10 mRNA were expressed in the all groups. However, Q-PCR analysis showed that the TLRs expression in ectopic group was higher than other groups. Conclusion: Our finding suggested that TLRs is involved in endometriosis pathophysiology. It is shown that TNF-α and IL-1 were increased in endometriosis which these are products in TLR signaling.
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Journal title
volume 6 issue 2
pages -
publication date 2012-09-01
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