Lack of association between coding region of KCNE2 gene and the congenital long QT syndrome in an Iranian population

Authors

  • Ayyoob Khosravi Student Research Committee, Golestan University of Medical Sciences, Gorgan, Iran
  • Majid Haghjoo Shahid Rajaei Cardiovascular, Medical and Research Center Echocardiography Research Center, Tehran University of Medical Sciences, Tehran, Iran
  • Mehdi Gholizadeh Student Research Committee, Golestan University of Medical Sciences, Gorgan, Iran
  • Mehdi Zahedi Ischemic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran
  • Morteza Oladnabi Department of Human Genetics, School of Advanced Technologies in Medicine, Golestan University of Medical Sciences, Gorgan, Iran
  • Pedram Torabian Student Research Committee, Golestan University of Medical Sciences, Gorgan, Iran
  • Vahid Khori Ischemic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran
  • Yahya Jand Ischemic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran
Abstract:

Introduction: Congenital long QT syndrome (LQTS) is a cardiac disorder characterized by QT interval prolongation at basal ECG. Different LQTS genes encode ion channel subunits or proteins involved in regulating cardiac ionic currents. Long QT syndrome type 6 (LQT6) is caused by mutation in the KCNE2 gene. Our research aimed to analyze genetic variants of KCNE2 gene causing the disease in Iranian population. Methods: Twenty nine patients consented for participation in the study. They were diagnosed based on Schwartz's criteria. After DNA extraction from peripheral blood cells, two exons of the KCNE2 gene were amplified. Afterwards, PCR-SSCP was carried out for screening the possible mutated gene variants. As the last verification step, direct sequencing was done to determine the sequence. Results: All samples were detected by PCR-SSCP and sequenced. None of the patients had the mutation in the KCNE2 gene. Conclusion: Investigating a genetic variant associated with LQTS, in Iranian patients clinically diagnosed with LQT6, no association was found between the disease and KCNE2 gene. Other previously identified genes, especially the major genes, should be considered for further investigation.

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Journal title

volume 20  issue None

pages  172- 178

publication date 2016-08

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