Investigation of KCNJ11 Gene Variant (rs 5219) in Patients with Diabetes after Liver Transplantation

Authors

  • Azarpira, Negar Transplant Research Center, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
  • Kazemi, Kurosh Transplant Ward, Shiraz University of Medical Sciences, Shiraz, Iran
  • Kohan, Leila Department of Biology, Arsanjan Branch, Islamic Azad University, Arsanjan, Iran
  • Parvizi, Mohammad mahdi Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  • Parvizi, Zahra Department of Biology, Arsanjan Branch, Islamic Azad University, Arsanjan, Iran
Abstract:

Background & Objective: The incidence of diabetes in liver transplant recipients is one of the common problems among these patients witha negative effect on the success of the transplant and the patient's life. Post Transplant Diabetes Mellitus (PTDM) has many similarities with type 2 diabetes from pathophysiplogical, clinical, and genetic viewpoints... One of the genotypes involved in PTDM is KCNJ11 (rs 5219) that has role in beta-cell function and has regulator effect on ATP sensitive K channels. The purpose of this study is to review the relation between this polymorphism and diabetes after liver transplantation in an Iranian population.Materials & Methods: This is a case-control study on 120 patients receiving liver transplant, including 60 patients with PTDM and 60 patients without PTDM. White blood cell samples were selected from the cell bank of organ transplantation research centre in Namazi Hospital from patients who had undergone liver transplantation during the years 2008 and2012. Frequency of genotypes in this population was determined by PCR-RFLP method. To express the results we used distribution indices and parametric statistical tests.Results: Statistical analysis shows that there is a significant difference between the genotype and the allele frequencies of the two groups of case and control.. KK genotype (P=0.001 95%CI (1.60-7.6) OR=1.19 increases the risk of PTDM. Conclusion: Our study shows that there is a relation between the incidence of PTDM and sex, age, prednisolone dosage, KCNJ11 polymorphism, and KK genotype. 

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Clinical and Molecular Genetic Analysis of Iranian Patients with Neonatal Diabetes demonstrating Mutations in KCNJ11 gene

Abstract We screened the KCNJ11 gene from 35 individuals clinically diagnosed with type 1 diabetes mellitus under the age of 6 months in 3 years duration. Six different heterozygous missense mutations were found in 7 of the 35 probands, which accounted for 20% of all individuals. A novel mutation W68R (No Locus, GU170814; 2009) was identified in the kir6.2, the pore-forming subunit of the KATP ...

full text

INVESTIGATION OF METHYLATION OF TNF-Α GENE PROMOTER IN PATIENTS WITH TYPE 2 DIABETES

Background: Type II diabetes is a chronic inflammatory condition that is associated with a combination of genetic and environmental factors. Tumor necrosis factor alpha or TNF-α as an adipocyte cytokine, which affects the signaling pathway of insulin, can contribute to insulin resistance in type 2 diabetes patients. Considering the importance of epigenetic changes in multifactorial diseases, th...

full text

randomized controlled trial study about compare of post operative pain after milligan morgan versus submucosal hemorrhoidectomy with & without pudendal nerve marcaine block in patients that had hemorrhoidectomy in imam hossein hospital of shahrood in 1389-90

مقدمه:هموروئید یکی از شایعترین بیماریهای جراحی ناحیه آنورکتال است که با درد و خونریزی بروز می کند. کاهش دردبعد عمل علاوه بر افزایش رضایت بیمار باعث کاهش مدت بستری و کاهش بار تحمیلی بر روی اقتصاد جامعه می گردد. مطالعه حاضر مقایسه ای از لحاظ میزان درد و میزان تأثیر مارکائین به عنوان روشی برای پروفیلاکسی درد بعداز عمل،دو روش هموروئیدکتومی باز و بسته انجام می دهد. مواد وروشها: این مطالعه کارآزمایی...

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 4  issue 2

pages  233- 242

publication date 2014-09

By following a journal you will be notified via email when a new issue of this journal is published.

Keywords

No Keywords

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023