Interactive effect of exercise training with ω-3 supplementation on resting levels of TNF-α and IL-10 in Karat Men

Introduction: Perform heavy exercise training, causing a variety of changes including a reduction in performance. Few human studies have been examined of supplemental ω-3 and exercise, then the aim of this study was to study the interactive effect of exercise and ω-3 on resting levels of TNF-α and IL-10 in elite Karate and compared with untrained. Methods: In this quasi-experimental study 42 healthy young male elite karate and non-athletes, were randomly divided into study groups. Athletes: 1- ω -3 and exercise, 2- placebo and exercise,3- exercise  and non-athletes: 1- ω -3, 2- placebo,3- control. Athletes groups performed pre-season practice in 65% to 80% VO2 max. Consumption of ω -3 was 1800mg/day for 4 weeks. Blood sampling done 48 hours before, 12 hours fasting after protocol. TNF-α and IL-10 were measured by ELISA and LDL, HDL Enzymatic methods. Results: Exercise training with ω-3 for 4 weeks do not have a significant effect on resting levels of IL-10 ،TNF- α، HDL و LDL (P>0.05). Then ω-3 do not have a significant effect in non-athletes (P>0.05). Conclusion: The results showed  that Although the consumption of ω-3 do not have significant changes  in TNF-α and IL-10, but can slightly reduced TNF-α and increase in the IL-10, that confirm its positive effects on inflammatory factors. However, more research seems necessary in this context.