Inhibitory Effect of E. coli Nissle 1917 on Clinical and Standard Strains of Pseudomonas aeruginosa

Background and purpose: Pseudomonas aeruginosa is an indispensable pathogenic agent that can lead to serious infections. Antibiotic resistance is really common among bacteria, so, new therapeutic agents could be of great help in overcoming this problem. Based on previous studies, probiotic strains have a protective effect against pathogenic or Image result for opportunist bacteria opportunistic bacteria thorough various mechanisms. The main purpose of the present study was to evaluate the influence of E. coli Nissle 1917 as a probiotic strain on Pseudomonas aeruginosa strains. Materials and methods: In this experimental study, MIC and Disk Diffusion techniques were used to investigate the effect of E. coli Nissle 1917 on Pseudomonas aeruginosa strains. Effect of antibacterial activity of the probiotic strain was evaluated after 24h at 37°C. Results: The highest concentration of E. coli Nissle 1917 showed the most effective antibacterial activity against clinical and standard Pseudomonas aeruginosa strains after 24h. Conclusion: Probiotic bacteria can have a positive effect on medical aspects, especially because of having access to numerous antibiotic resistance pathways. Therefore, due to lack of suitable antibiotics for several infections, probiotics could be highly helpful. Various concentrations of probiotic bacteria can also inhibit the pathogenic strain.