In vitro comparison of Anti-Candidal Activity of cinnamon and Querques infectoria hydroalcholic extracts with nystatin in treatment of denture stomatitis

Abstract   Background and Aim: Candida albicans play the main role in the onset, preservation and progression of denture stomatitis. Therefore, the present study was conducted with the aim of comparing the anti candidal effect of cinnamon and Querques infectoria extracts with nystatin for treatment of denture stomatitis. Materials and methods: In this experimental study, 43 patients with clinical diagnosis of denture stomatitis were selected and maxillary dentures were taken for 24 hours. Dentures randomly were divided into three groups of 14 tests and one denture was considered as a negative control group for immersion in distilled water. From the tissue surface, all dentures were sampled with swab and the samples were transferred to the laboratory after transfer to the culture medium and the colony count (CFU / mm2) was measured. Then, each of the 14 denture groups were immersed in a hydroalcoholic solution of cinnamon (70%), a hydroalcoholic solution of Querques infectoria (70%) and nystatin suspension for 24 hours. After 24 hours, repeat sampling and colony count was measured and then the colony count before and after immersion was compared. Data was analyzed using SPSS17 statistical software, Chi-square, Fisher exact tests and ANOVA. Results: There was no significant difference between the three groups obtained colony counts of Candida albicans from dentures (P-value = 0.01). Conclusion: Both herbal extracts could be effective on treatment of denture stomatitis. It should be more evaluated in future studies.