Improving methodology for the preparation of highly substituted imidazoles using nano-MgAl2O4 as catalyst under microwave irradiation
Authors
Abstract:
An efficient synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetrasubstituted imidazoles by one-step condensation of an aldehyde, benzil, ammonium acetate and primary amine in the presence of nanocrystalline magnesium aluminate under microwave irradiation is described. The advantages of this catalyst are including simple work-up, low cost and reusability. Compared with conventional methods, the main advantages of the present procedure are its being a green method, its milder conditions, necessary shorter reaction time, and its higher yields and its selectivity. The structures of products were characterized by 1H NMR, 13C NMR, IR, elemental analyses, MS and UV spectral data. Their melting points were compared with literature report.
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improving methodology for the preparation of highly substituted imidazoles using nano-mgal2o4 as catalyst under microwave irradiation
an efficient synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetrasubstituted imidazoles by one-step condensation of an aldehyde, benzil, ammonium acetate and primary amine in the presence of nanocrystalline magnesium aluminate under microwave irradiation is described. the advantages of this catalyst are including simple work-up, low cost and reusability. compared with conventional methods, the ...
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full textMagnetic Fe3O4 nanoparticles as a highly efficient catalyst for the synthesis of imidazoles under ultrasound irradiation
To be fairly general and catalyst is easily separated by magnetic devices and can be reused without any apparent loss of activity for the reaction. Fe3O4 nanoparticles were prepared by chemical coprecipitation method and was found to be a mild and effective catalyst for the efficient, one-pot, three-component synthesis of 2,4,5-trisubstituted imidazoles at room temperature under ultrasound irra...
full textmagnetic fe3o4 nanoparticles as a highly efficient catalyst for the synthesis of imidazoles under ultrasound irradiation
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Journal title
volume 3 issue 1
pages 33- 39
publication date 2013-03-01
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