Histomorphometric Comparison of 2 types of FDBA and DFDBA bone powders manufactured by Faravardehaye Peyvandi Iran Company in treatment of defects in rabbit calvaria bone

Abstract Background and Aim: Allografts are a group of grafting materials in two types of DFDBAs and FDBAs with various applications in restoration of osseous defects. Considering high price of foreign brands of these materials, we decided to launch a study and compare 2 types of FDBA and DFDBA osseous powders manufactured by Faravardehaye Peyvandi Iran Company and their application in restoration of calvaria bone damages in rabbits. Materials and Methods: The research performed on randomized clinical trial on 12 white rabbits.We made 4 full thickness 8 millimeter defects in calvaria bones of each rabbit. Then, in two groups, DFDBA and FDBA were used and other two groups were the positive and negative control group. Within the 2 consecutive months (2,4,6, and 8 weeks) every session, 5 rabbits were sacrificed and removed the calvaria bone for histologic and histomorphometric study. Data were analyzed using Friedman and Kruskal-Wallis and Wilcoxon tests. We utilized SPSS ver:20 software. Results: There were no statistically significant differences between FDBA and DFDBA groups regarding the inflammation and amount of resorption .In the filling status of the defect, DFDBA group was significantly better than FDBA group. (p<0.05) At the end of 4 weeks in both groups, bone powder was completely absorbed. Foreign body reaction and complete remodeling of bone was not observed in both groups during the study period. Conclusion: Both FDBA and DFDBA groups were similar regarding the inflammation and amount of resorption. In the filling status of the defect, DFDBA group was preferred vs. FDBA group.