Evaluation the Efficiency of Paprika Drug on Liver Enzymes and Lipid Metabolism Changes Following Oxytetracycline Administration in Rats

Background: The aim of the present study was to investigate the effect of Paprika on the metabolism of lipid changes and hepatic enzyme activities following oxytetracycline administration in rats. Materials and Methods: A total of 36 adult male rats were divided into 6 equal groups and treated as follows. The control group (normal saline), fatty liver  FL (oxytetracycline (Erfan drug Company) with dosage120 mg/kg per day for 3 days), fatty liver group-1 treatment  FL1(oxytetracyclinefor three days, then the extract of Paprika daily 75 mg/kg by stomach tube for thirty days), liver-fatty-therapeutic group FL2 (oxytetracycline for three days, then Paprika per day 100 mg/kg by stomach tube for thirty days), pretreatment group 3  FL3 (Paprika 75 mg/kg daily with gastric tube for 15 days then oxytetracycline for three days) and pretreatment  group 4 FL4 (Paprika 100 mg/kg daily with gastric tube for 15 days followed by oxytetracycline for 3 days.  Results: Pre-treatment with Paprika at dose 100 mg/kg resulted in a significant decrease in AST level compared to the control group (P <0/05). Pre-treatment of Paprika with a dose of 75 mg resulted in a significant decrease in ALT level compared to the control group (p <0.01). Also, pretreatment with Paprika at dose of 100 mg resulted in a significant decrease in ALT level compared to control group and all of the other groups (P <0.001). Serum total cholesterol concentration in the fatty liver group had a significant increase compared to control, fatty liver, FL 3 and 4 groups (P <0.001). The concentration of triglyceride in the fatty liver group was significantly higher than that of the pretreatment group 4 (P <0.001). The concentration of HDL in the pretreatment group 4 showed a significant increase compared to the control, fatty liver and FL1 groups (p <0.01) and in the pretreatment group 3 compared to the fatty liver and FL1 groups (p <0.01). Conclusion: It seems that Paprika extract have a positive effect on the prevention of liver poisoning, lipid metabolism changes and protective effects against hepatic enzyme activities in rats.