Evaluation of Protective Antibody Titer Against HBs Antigen in Students of Gonabad University of Medical Sciences in 2018

Aim: Hepatitis B infection is one of the common diseases worldwide and the most prevalent communicable virus transferred by blood to the healthcare personnel. Active immunity, due to vaccination is the most effective way to prevent hepatitis B infection. The present study aimed at determining protective antibody titer against HBs antigen in Gonabad University of Medical Sciences students in Iran, 2018. Materials and Methods: The present cross sectional study were conduct on 416 students of Gonabad University of Medical Sciences. The HBsAb level was determined in blood samples by enzyme-linked Immunosorbent Assay (ELISA) kit made in Iran. Independent t test, chi-square test were used to analyze the data. The level of significance was < 0.05. Results: HBsAb level of 217 (51.8%) cases was below 10 mIU/L, 96 (61.3%) had an HBsAb level between 10 and 100 mIU/L, and in 106 (36.5%) cases, HBsAb level was above 100 mIU/L. There was no statistically significant difference among the means of HBsAb in terms of gender, age, and BMI (P<0.05). Conclusions: In general, it can be conclude that more than 50 percent of participant in this study had mild immunity in contrast of Hepatit B viruses. Therefore, in these people, it is recommended to check the antibody titer periodically to ensure immunity against hepatitis B.