Evaluation of Immature Neutrophil Ratio and Calprotectin Level for the Diagnosis of Neonatal Sepsis

Authors

  • Hassan Boskabadi Department of Pediatrics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  • Hossein Ayatollahi Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  • Maryam Sheikhi Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  • Mohammad Reza Keramati Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  • Sepideh Shakeri Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  • Seyyede Fatemeh Shams Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Abstract:

Background: Sepsis is defined as a systematic inflammatory reaction against infection. Despite the recent advances in medical and pediatric sciences, sepsis remains a significant life-threatening health issue. The main problem associated with this disorder is the nonspecific and non-discriminative symptoms of noninfectious diseases. The present study aimed to introduce diagnostic parameters of high sensitivity and specificity for neonatal sepsis.Methods: This case-control study was conducted in Mashhad, Iran during 2013-2015. Subjects included 40 septic neonates with confirmed diagnosis by a subspecialist of pediatrics and 40 neonates without clinical and laboratory findings of sepsis as the control group. Blood samples were collected from all the infants. In addition, differential white blood cell count of peripheral blood smear was performed, and immature/total neutrophil ratio (I/T) was calculated for all the PBS slides. Plasma calprotectin levels were also determined using the sandwich ELISA method.Results: Mean plasma concentration of calprotectin was 33190±23760 and 18980±13410 ng/ml in the septic and control groups, respectively. Moreover, mean I/T was 0.61±0.22 and 0.51±0.26 in the septic and control groups, respectively. The obtained results indicated that calprotectin levels and I/T were significantly higher in the septic group compared to the control group (P

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Journal title

volume 8  issue 3

pages  19- 24

publication date 2017-09-01

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