Evaluation of clinical and histological parameters in patients with oral squamous cell carcinoma referred to Tehran Faculty of Dentistry (1966 – 2002)

Evaluation of clinical and histological parameters in patients with oral squamous cell carcinoma referred to Tehran Faculty of Dentistry (1966 – 2002) Dr. N. Eshghyar* - Dr. P. Motahari** - Dr. A. Khorshidian*** *- Associate Professor of Oral & Maxillofacial Pathology Dept.- Faculty of Dentistry-Tehran University of Medical Sciences. **-Assistant Professor of Oral & Maxillofacial Pathology Dept.-Faculty of Dentistry-Tehran University of Medical Sciences. *** - Dentist. Background and Aim: Squamous cell carcinoma (SCC) is the most prevalent neoplasm in oral cavity and due to the numerous complications arising from lesions or treatment and its high mortality rate has been paid too much attention. The goal of the present study was to evaluate clinical and histological parameters in patients with SCC referred to Pathology department, Dentistry Faculty, Tehran University of Medical Sciences. Materials and Methods: In this case series study, clinical and histological information of 271 patients affected with SCC were collected through the evaluation of all documents in pathology department from 1966 to 2002. All surgical documents and histological slides were studied and analyzed using SPSS version 11.0 X2 test and t test. Results: Malignancy score was higher in males than females. The maximum, minimum and average age of patients were 85, 19 and 56.73 years, respectively. The majority of lesions were observed during the sixth decade of life and the ratio of males to females was 5:4. Malignancy score, in young patients, was higher than old ones. The most common site for lesions was mandibular ridge and the least common was the upper lip. Lesions of maxillary sinus and soft palate had the highest and lesions of the upper lip had the lowest malignancy score. 74% of the patients were smokers. Most of the lesions showed high keratinization, slight inflammation and polymorphism and were of grade I. Conclusion: SCC incidence is more common among males compared to females. Patients older than 50 years are considered as the high risk group for this neoplasm. Mandibular ridge is the most common site. Majority of the lesions are well differentiated in oral cavity. Malignancy score is higher in males and young patients than females and old patients. Key words: Squamous cell carcinoma – Grading – Polymorphism.