Evaluation of anticonvulsant effect of aqueous and methanolic extracts of seven Inula species

Authors

  • Babak Gholamine Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences,Tehran,Iran.
  • Mehrdad Faizi Department of Pharmacology and Toxicology, School of Pharmacy, Shahid Beheshti University of Medical Sciences,Tehran, Iran.
  • Mona Khoramjouy Department of Pharmacology and Toxicology, School of Pharmacy, Shahid BeheshtiUniversity of Medical Sciences, Tehran, Iran.
  • Shamim Sahranavard Department of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract:

In Iranian traditional medicine, plants belonging to Inula genus have been used for the treatment of seizure. We decided to investigate the anticonvulsant activity of seven species from this genus to find an effective remedy for seizure with less adverse effects compared to available medicines. Aqueous and methanolic extracts of Inula britannica, Inula helenium, Inula viscidula, Inula oculus-christi, Inula aucheriana, Inula thapsoides and Inula salicina were prepared and their antiepileptic activity was investigated by maximal electroshock and pentylentetrazole tests. Diazepam was used as positive control in both tests. Two extracts with the best anticonvulsant activities were selected and their sedative and hypnotic effects were evaluated using open field and righting reflex tests respectively. The effects of both extracts on memory and motor coordination were also assessed by step-through passive avoidance and rotarod tests respectively. Aqueous extract of Inula britannica and Inula viscidula showed the best activity in MES model and their ED50 was 19.5(7.9~48.5)mg/kg and 12.7(10.0~16.3)mg/kg respectively. None of the extracts showed noticeable anticonvulsant effects in the PTZ model. The active extracts showed sedative-hypnotic effects in righting reflex and open field tests. Both extracts did not affect the memory and motor coordination in the experimental model. The anticonvulsant and sedative activities of the extracts were antagonized by flumazenil, indicating that benzodiazepine receptors are probably involved in the effects. Finally, Inula britannica and Inula viscidula are good candidates for further phytochemical and mechanistic studies in order to find anticonvulsant and sedative-hypnotic agents with less adverse effect on memory and motor coordination.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

detection of volatile compounds of medicinal plants with some nano-sorbents using modified or new methodologies and investigation of antioxidant activity of their methanolic extracts

in this work, a novel and fast method for direct analysis of volatile compounds (davc) of medicinal plants has been developed by holding a filament from different parts of a plant in the gc injection port. the extraction and analysis of volatile components of a small amount of plant were carried out in one-step without any sample preparation. after optimization of temperature, extraction time a...

the evaluation of language related engagment and task related engagment with the purpose of investigating the effect of metatalk and task typology

abstract while task-based instruction is considered as the most effective way to learn a language in the related literature, it is oversimplified on various grounds. different variables may affect how students are engaged with not only the language but also with the task itself. the present study was conducted to investigate language and task related engagement on the basis of the task typolog...

15 صفحه اول

the effect of functional/notional approach on the proficiency level of efl learners and its evaluation through functional test

in fact, this study focused on the following questions: 1. is there any difference between the effect of functional/notional approach and the structural approaches to language teaching on the proficiency test of efl learners? 2. can a rather innovative language test referred to as "functional test" ge devised so so to measure the proficiency test of efl learners, and thus be as much reliable an...

15 صفحه اول

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 18  issue Special Issue

pages  208- 220

publication date 2019-12-01

By following a journal you will be notified via email when a new issue of this journal is published.

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023