Efficacy of Omega 3-6-9 fatty acids, alone or in combination with low dose aspirin, in the improvement of uterine blood flow in women with history of recurrent miscarriage: A prospective, randomized, clinical trial.

Background & Objectives: Recurrent miscarriage (RM) occurs in some women. There is much evidence that increased uterine blood flow resistance (reduced uterine perfusion) increases the risk of RM. This study was aimed at evaluating the efficacy of Omega 3-6-9 fatty acids, alone or in combination with aspirin, in the reduction of uterine blood flow resistance in women with a history of RM. Methods: 45 women with a history of two or more miscarriages, showing increased uterine artery blood flow resistance, were included in this randomized clinical trial and were randomly assigned to aspirin (80mg/day) (N=15), Omega 3-6-9 fatty acids (4800 mg/day) (N=15) or combination therapy (N=15). The patients were visited after two months and the uterine artery blood flow resistance was measured by Doppler sonography. Results: Average of participants were 32±3.5 y in group A, 32±3 in group O and 32.4±3 in group AO. There was no significant difference between three groups in age (P value= 0.7), duration of marriage (P value= 0.55), duration of infertility (P value= 0.43) and Number of previous miscarriages (P value= 0.51). In all of the three groups, after two months of treatment, the average uterine artery blood flow resistance was reduced considerably compared with the beginning of the trial (P value=0.0001); however, there was no significant difference between the three groups (P value=0.56). Conclusions: According to the results of this study, Omega 3-6-9 fatty acids are able to reduce the uterine artery blood flow resistance and improve the uterine blood flow in women with RM, with equal efficacy to aspirin. But Combination therapy offers no advantages over monotherapy.