Effect of Particle Size, Compaction Force and Presence of Aerosil 200 on the Properties of Matrices Prepared from Physical Mixture of Propranolol Hydrochloride and Eudragit RS or RL

Authors

  • Fatemeh Mosaffa School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
  • Fatemeh Sadeghi Department of Pharmaceutics, School of Pharmacy and Pharmaceutical Research Center, Mashhad University of Medical sciences, Mashhad, Iran
  • Hadi Afrasiabi Garekani Department of Pharmaceutics, School of Pharmacy and Pharmaceutical Research Center, Mashhad University of Medical sciences, Mashhad, Iran
Abstract:

Objective Eudragits are widely used polymers in the production of oral sustained release dosage forms. The application of these polymers in the production of inert insoluble matrices has been investigated. However the effect of particle size, compaction force and presence of Aerosil 200 as a glidant on the properties of Eudragit RS and RL matrices prepared by direct compression of their physical mixtures with drug have not been fully investigated. This study was performed in order to investigate the effect of above mentioned factors on physicomechanical and release properties of propranolol hydrochloride and Eudragit RS or RL matrices. Materials and Methods Polymers were separated to different size fractions using series of sieves. Matrices were prepared in 1:3 ratio by direct compression of physical mixture of drug and polymer. To study the effect of Aerosil 200, matrices were prepared from different size fractions containing 1%w/w Aerosil 200. To investigate the effect of compaction force, the 125-177µm size fraction of polymer was chosen and compression carried out at 5, 10, 15, 20 and 30 kN compaction force. Matrices were characterized for their hardness and dissolution. Results The results showed that due to decrease in tablet hardness the release rate increased with increase in polymer particle size. Drug release rates were almost the same for both polymers at similar particle size range. The same trend was also observed for matrices containing Aerosil 200. Addition of Aerosil 200 decreased the rate of drug release from all matrices except those prepared from 250-350 µm size fraction. This was attributed to increase in the tablet hardness. Increase in compaction force from 5kN to 20kN increased the tablet hardness and consequently decreased the release rate, however, further increase in compaction force from 20 to 30 kN did not significantly affect the release rates of drug. Conclusion Polymer particle size, presence of Aerosil and compaction force are important factors affecting drug release from Eudragit RS or RL matrices. Eudragit RS and RL polymers alone are not suitable for preparation of sustained release matrices containing water soluble drugs.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

effect of particle size, compaction force and presence of aerosil 200 on the properties of matrices prepared from physical mixture of propranolol hydrochloride and eudragit rs or rl

objective eudragits are widely used polymers in the production of oral sustained release dosage forms. the application of these polymers in the production of inert insoluble matrices has been investigated. however the effect of particle size, compaction force and presence of aerosil 200 as a glidant on the properties of eudragit rs and rl matrices prepared by direct compression of their physica...

full text

the effect of task complexity on lexical complexity and grammatical accuracy of efl learners’ argumentative writing

بر اساس فرضیه شناخت رابینسون (2001 و 2003 و 2005) و مدل ظرفیت توجه محدود اسکهان (1998)، این تحقیق تاثیر پیچیدگی تکلیف را بر پیچیدگی واژگان و صحت گرامری نوشتار مباحثه ای 60 نفر از دانشجویان زبان انگلیسی بررسی کرد. میزان پیچیدگی تکلیف از طریق فاکتورهای پراکندگی-منابع تعیین شد. همه ی شرکت کنندگان به صورت نیمه تصادفی به یکی از سه گروه: (1) گروه موضوع، (2) گروه موضوع + اندیشه و (3) گروه موضوع + اندی...

15 صفحه اول

determination of some physical and mechanical properties red bean

چکیده: در این تحقیق، برخی خواص فیزیکی و مکانیکی لوبیا قرمز به-صورت تابعی از محتوی رطوبت بررسی شد. نتایج نشان داد که رطوبت بر خواص فیزیکی لوبیا قرمز شامل طول، عرض، ضخامت، قطر متوسط هندسی، قطر متوسط حسابی، سطح تصویر شده، حجم، چگالی توده، تخلخل، وزن هزار دانه و زاویه ی استقرار استاتیکی در سطح احتمال 1 درصد اثر معنی داری دارد. به طوری که با افزایش رطوبت از 54/7 به 12 درصد بر پایه خشک طول، عرض، ضخام...

15 صفحه اول

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 10  issue 3

pages  197- 205

publication date 2007-07-01

By following a journal you will be notified via email when a new issue of this journal is published.

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023