Effect of Molybdenum Trioxide Nanoparticles on Ovary Function in Female Rats

Authors

  • Ahmad Jalilvand Dept. of Pathology, Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran
  • Azam Heidari Dept. of Biochemistry, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
  • Fardin Asadi Dept. of Pediatrics, Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran
  • Keivan Nedaei Dept. of Medical Biotechnology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
  • Mansour Sadeghzadeh Dept. of Pediatrics, Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran
  • Yasamin Asadi National Nutrition of Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract:

Background & Objective:  Molybdenum trioxide nanoparticles (MoO3 NPs) have widespread applications in industries. However, the toxic and non-toxic effects of MoO3 NPs have not been fully investigated yet. In this study, effects of MoO3 NPs on ovary function of female rats were studied.  Materials & Methods:  In this study, 21 female rats were randomly divided into three groups (n=7): the first group did not receive any treatment, the second one received normal saline, and the third group received 5 mg/kg MoO3 NPs in normal saline via intraperitoneal injection during a period of 28 days. Serum concentrations of estrogen, progesterone, luteinizing hormone, and follicle stimulating hormone were measured. Also, changes of ovaries, uterine weights, uterine, and length of uterine horns were studied. Results:  The serum level of estrogen in the MoO3 NPs exposed group was significantly attenuated; those of luteinizing hormones and follicle stimulating hormone were elevated while progesterone level change was insignificant. The weights of the right ovary and the uterine body decreased significantly in the exposed group. Conclusion:  Our data showed that MoO3 nanoparticle exposure could cause an imbalance of sex hormones and decrease in body and ovarian weights in thefemale rats.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Effect of Molybdenum Trioxide Nanoparticles (MoO3 NPs) on Thyroid Hormones in Female Rats

Background; In recent years, nanoparticles have been increasingly used in industries. However, there is a serious lack of information concerning their impact on human health and the environment. This study was investigated the effect of MoO3 NPs on thyroid hormones in female rats. Methods; In this study, 21 female Wistar rats were selected and divided into three groups of untreated control, sh...

full text

effect of molybdenum trioxide nanoparticles (moo3 nps) on thyroid hormones in female rats

background; in recent years, nanoparticles have been increasingly used in industries. however, there is a serious lack of information concerning their impact on human health and the environment. this study was investigated the effect of moo3 nps on thyroid hormones in female rats. methods; in this study, 21 female wistar rats were selected and divided into three groups of untreated control, sha...

full text

effect of molybdenum trioxide nanoparticles on thyroid hormones in female rats

background: in recent years, nanoparticles have been increasingly used in industries. however, there is a serious lack of information concerning their impact on human health and the environment. this study was investigated the effect of moo3 nps on thyroid hormones in female rats. methods: in this study, 21 female wistar rats were selected and divided into three groups of untreated control, sha...

full text

Alteration in capacity and function of proximal and distal convoluted tubules in kidney exposed by Molybdenum trioxide nanoparticles in female rats (Stereological technique)

Background: One of the applications of molybdenum trioxide nanoparticles (MTNPs) is to use it as an antibacterial agent. The kidney is also one of the most important organs in the body to excrete waste products and regulate many blood factors. Duo to widespread use of MTNPs and the importance of the kidney, the aim of this study was to investigate this drug effect on kidney tubules. Materials ...

full text

the effect of aqueous extract of garlic on formalin-induced pain in male rats

چکیده اثر عصاره آبی سیر بر درد ناشی از آزمون فرمالین در موش صحرایی نر به کوشش نرگس اسکندری روزبهانی زمینه و هدف: گیاه سیر از خانواده لیلیاسه و گونهallium sativum بومی آسیای میانه بوده و از دوران ،باستان تاکنون به خواص درمانی متفاوت آن مثل: کاهندگی قندخون، کلسترول خون، فشار خون، اثرات مفیدآن بر دستگاه قلبی عروقی و بیماریهای انعقادی خون، اثرات آنتی اکسیداتیو، درمان بیماریهای تنفسی وگوارشی، ا...

15 صفحه اول

Studying the toxicity of molybdenum trioxide nanoparticles in male Wister rats

Background: With the spread of nanotechnology, various nanoparticles with new and emerging properties have been produced and the potential toxic effects of the majority of these particles remains still unknown. The present study was conducted to determine the toxicity of Molybdenum Trioxide nanoparticles in blood and body tissues of male Wistar rats. Materials and Methods: Thirty Wistar rats w...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 27  issue 121

pages  48- 53

publication date 2019-03

By following a journal you will be notified via email when a new issue of this journal is published.

Keywords

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023