Effect of Eight-Week Aerobic Moderate-Intensity Continuous Training on Il-1β and Il-13 Levels of Soleus Muscle Tissue in Male Diabetic Rats

Background: One consequence of diabetes mellitus is increased inflammation, which is exacerbated by training. The objective of this study was to evaluate the effect of eight weeks of aerobic moderate-intensity continuous training on Interleukin-1 beta, Interleukin-13 responses in male Wistar diabetic rats. Methods: 36 diabetic rats were randomly assigned into 3 equal groups (control (C), diabetic (D), and diabetes + training (D + T)), and subjected to eight weeks of aerobic moderate- intensity continuous training intensity at the first: the10 min on 10m/min and at the final: 55min on 26m/min speed. Interleukin-1 and interleukin-13 were measured in soleus muscle tissue to examine the pro-inflammatory and anti-inflammatory indicators. ANOVA and Scheffe post hoc tests were used for data analysis. Results: Induction of diabetes caused a significant increase in IL-1β and IL-13 (P<0.001) and continuous exercise intervention also significantly reduced IL-1β levels in diabetic rats (P = 0.02). However, there was no significant change in IL-13 in D + T group compared to D group (P = 0.985). Conclusion: According to the results of this study, the effect of aerobic exercise is probably a positive effect on reducing the pro-inflammatory index of IL-1β and no effect on the anti-inflammatory index of IL-13 in diabetic rats. However, definitive confirmation of these results requires further research in this area.