Development and Validation of a GC/MS Method for Simultaneous Determination of 7 Monoterpens in Two Commercial Pharmaceutical Dosage Forms

Authors

  • Ali Goodarzi Incubation Center for Pharmaceutical Technologies, Shahid Beheshti University of Medical Sciences
  • Athar Ata Department of Chemistry, Richardson College of the Environmental Science Complex, The University of Winnipeg, Winnipeg, Canada.
  • Farzad Kobarfard Department of Medicinal Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran. | Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Marjan Esfahanizadeh Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Mitra Bayat Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Seyed Abdulmajid Ayatollahi Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. |Department of Medicinal Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran. | Department of Chemistry, Richardson College of the Environmental Science Complex, The University of Winnipeg, Winnipeg, Canada
Abstract:

Terpenes are active constituents of many pharmaceutical dosage forms with naturalproducts origin. One of the challenges in developing dosage forms with herbal originis their standardization as pharmaceutical products. GC-Mass is the most decisive andreliable technique to fulfill the requirements in this regard. In the present study, a reliable,rapid, and accurate method was developed for determination of 7 monoterpenoids in twoselected pharmaceutical dosage forms (rowatinex and rowachol soft gelatin capsules) by gaschromatography-mass spectrometry triple quadrupole selected ion monitoring GC/MS-TQSIM.The method was validated for various parameters such as precision, linearity, accuracy,solution stability, limit of detection, and quantification. The average recovery of terpens wasin the range of 91.6-105.7%. The method was proved to be repeatable with RSD in the rangeof 0.28-11.18 for all of the concentration levels. The developed method is simple, rapid, andsensitive and was applied for determination of alpha pinene, camphene, beta pinene, cineol,fenchone, borneol, trans-anethol and menthol in a few batches of rowachol and rowatinexcapsules purchased from local drug stores.

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Journal title

volume 17  issue Special Issue 2

pages  24- 32

publication date 2018-12-01

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