Crocin alleviates the local paw edema induced by histamine in rats

Authors

Amir Abbas Farshid Department of Pathobiology, Faculty of Veterinary Medicine, Urmia University, Urmia, I. R. Iran

Esmaeal Tamaddonfard Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, I. R. Iran

Leila Hosseini Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, I. R. Iran

Abstract:

Objective: Crocin, as an active constituent of saffron, has many biological functions including antioxidant and anti-inflammatory activities. The present study was aimed to investigate the effects of crocin and chlorpheniramine on local edema induced by histamine. Materials and Methods: Local edema was induced by subcutaneous injection of histamine (100 μl, 0.1%) in ventral surface of right hind paw. The thickness of paw was measured at 1 h before and 1, 2, 3 h after injection of histamine, using a fine caliper. The number of neutrophils in paw tissue sections was counted 3 h after intraplantar injection of histamine. Results: Intraperitoneal injection of crocin at doses of 100 and 200 mg/kg and chlorpheniramine at a dose of 10 mg/kg significantly (p

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