Component Analysis of the Illegal Handmade Pills and Capsules for Self-Medicating Substance Dependence in Tehran, Iran

Authors

  • Afsaneh Fard-Sanei Bahar Medical, Anatomical, Genetics, and Clinical Pathology Laboratory, Tehran, Iran
  • Ali Farhoudian Associate Professor, Substance Abuse and Dependence Research Center, University of Social Welfare and Rehabilitation Sciences AND Department of Psychiatry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  • Azadeh Olyaei Psychologist, Drug Abuse Prevention and Treatment Office, State Welfare Organization, Tehran, Iran
  • Hamid Reza Khoddami-Vishteh General Practitioner, Substance Abuse and Dependence Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
  • Hooman Narenjiha General Practitioner, Substance Abuse and Dependence Research Center, University of Social Welfare and Rehabilitation Sciences AND Yalda Yaran Mehr Society, Tehran, Iran
  • Monir Fekri Bahar Medical, Anatomical, Genetics, and Clinical Pathology Laboratory, Tehran, Iran
  • Roya Noori Substance Abuse and Dependence Research Center, University of Social Welfare and Rehabilitation Sciences AND Yalda Yaran Mehr Society, Tehran, Iran
Abstract:

Background: To self-medicate substance dependence, many substance users consume herbal medicines delivered in herbal medicine shops which are prepared through non-standard methods using a variety of different materials. Hence, the present study was carried out aiming to investigate and analyze the content of such herbal medicines.Methods: Four herbal medicine shops were selected from each of the 22 zones of Tehran City, Iran, and a total of 95 samples were purchased. A package containing 6 types of medication that was advertised by a satellite TV channel, was also purchased. Using high-performance liquid chromatography (HPLC) method, the samples were analyzed in the laboratory to detect different types of materials.Findings: Among the samples, 23 and 72 samples were uncovered compressed pills (Dragon pills) and capsules filled with colored powders (handmade drug-quitting capsules), respectively. The package advertised in the satellite TV was prepared in 6 various forms. The most common substances present in all the samples were as follows: diphenoxylate, tramadol, opioids, acetaminophen, and codeine with values of 90%, 86%, 78%, 69%, and 68%, respectively. On average, 5 of the above mentioned substances were present in each sample; moreover, 63% of the samples contained 5 or more substances. In addition, 42 (41%) of the samples contained all the 5 main substances including opioids, codeine, tramadol, diphenoxylate, and acetaminophen.Conclusion: The findings of this study showed that handmade capsules and pills used for quitting addiction and also medicines advertised in the satellite TV channels contain different amounts of opioids, amphetamine, benzodiazepines, tramadol, codeine, and other substances that cause problems for substance users who are going to abandon substance abuse.

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Journal title

volume 10  issue 1

pages  17- 23

publication date 2018-08-01

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