Comparison of the Serum Level of Carcinoembryonic antigen, Prolactin, and Malondialdehyde in Patients Suffering from Breast Cancer and in Healthy individuals in Isfahan

 Background & Objective: One of the most prevalent types of cancer among women is breast cancer. The objective of this study is to compare the serum level of tumor marker of Carcinoembryonic Antigen (CEA), Prolactin, and oxidative marker Malondialdehyde (MDA) in patients with breast cancer and in control groups.  Materials & Methods: This case control study was carried out on the people who went to Seyedo Shohada Hospital in Isfahan. The experimental group was composed of 44 patients with breast cancer who were under treatment and the control group consisted of 44 healthy people. The amount of CEA and Prolactin was measured via ELISA, while the measurement of MDA was made manually and on the basis of reaction to Thiobarbituric acid. Results: The results of the current study indicated that the mean concentration of CEA in patients with breast cancer (2.175 ± 1.78ng/ml) was significantly greater than that of healthy people (1.161 ± 0.85ng/ml) (P < 0.001). The mean concentration of prolactin in patients with breast cancer and in healthy people were not significantly different, and the mean concentration of MDA of the patients with breast cancer (1.44 ± 0.37µ  mol/dl ) was significantly greater than that of the healthy people(1.27 ± 0.25µ  mol/dl ) (P < 0.01.( Conclusion: CEA can be used as a valuable serum marker in the efficacy of the treatment procedure as well as the diagnosis of metastatic breast cancer. Moreover, the role of lipid peroxidation as an effective process in the formation of breast cancer was confirmed.