Combined effects of PEGylation and particle size on uptake of PLGA particles by macrophage cells

Authors

  • Bahman Khameneh Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran|Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran
  • Fatemeh Mosaffa School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran|Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  • Mohsen Tafaghodi School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran|Nanotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  • Tina Moayedian School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
Abstract:

Objective:At the present study, relationship between phagocytosis of PLGA particles and combined effects of particle size and surface PEGylation was investigated.  Materials and Methods:Microspheres and nanospheres (3500 nm and 700 nm) were prepared from three types of PLGA polymers (non-PEGylated and PEGylation percents of 9% and 15%). These particles were prepared by solvent evaporation method. All particles were labeled with FITC-Albumin. Interaction of particles with J744.A.1 mouse macrophage cells, was evaluated in the absence or presence of 7% of the serum by flowcytometry method.  Results:   The study revealed more phagocytosis of nanospheres. In the presence of the serum, PEGylated particles were phagocytosed less than non-PEGylated particles. For nanospheres, this difference was significant (P

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Journal title

volume 2  issue 4

pages  299- 304

publication date 2015-10-01

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