Calixtyrosol: a Novel Calixarene Based Potent Radical Scavenger

The oxidative stress causes many diseases in human, therefore antioxidants have a specialposition in the medicinal chemistry. Tyrosol is an important antioxidant with a plenty ofbiological properties. There are many strategies such as clustering single drug units in orderto develop new drugs. The cluster effect can increase drug effects relative to single drug unit.Calixtyrosol is the novel cluster of tyrosol that shows a more effective antioxidant activity thansingle tyrosol. In fact, tyrosol can be considered as 1/4 of the cluster.Four hydroxyethyl moieties have been grafted at the upper rim of the calix[4]arene in allsynorientation, giving novel agent in the field of antioxidant agents. Free radical scavengingtests were determined by the 2, 2-diphenyl-1-picrylhydrazyl radical in methanol for fourantioxidants: calixtyrosol, tyrosol, hydroxytyrosol and 3, 5-di-tert-buty l-4-hydroxytoluene tocompare their antioxidant activity.Free radical scavenging test showed that calixtyrosol has enhanced antioxidant activity incomparison to the corresponding single tyrosol unit (> 5 fold), it has even more active than theother test antioxidants (2 fold). Presumably, it is attributed to tethering and arraying of fourimpacted tyrosol units, which make a synergistic effect in interactions with radicals for creatingeffective radical scavenging activity.This method is in debt of synergistic effect, tethering and arraying of single units in thecluster structure.