Brønsted Acidic Ionic Liquid: An Efficient and Reusable Catalyst for the Multi-Component Synthesis of Dihydropyrimidinones under Solvent-Free Conditions

Authors

  • Heshmatollah Alinezhad Department of Organic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran
  • Neda Ghobadi Department of Organic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran,
Abstract:

An efficient and convenient procedure for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones and thiones by condensation of 1,3-dicarbonyl compounds, Aromatic and aliphatic aldehydes, and urea or thiourea in the presence of catalytic amount of Brønsted acidic ionic liquid 3-methyl-1-sulfonic acid imidazolium chloride {[Msim]Cl} under thermal solvent-free conditions reacted easily to afford the corresponding 3,4-dihydropyrimidin-2(1H)-ones and thiones. Straightforward and clean workup, short reaction time, good to excellent yields and reusability of the catalyst are the advantages of this method.

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Journal title

volume 8  issue 3

pages  41- 48

publication date 2018-10-15

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