Biological Evaluation of the Isolated Compounds from Methanol fraction of Leutea avicennia Mozaff.
Authors
Abstract:
Leutea avicenniae Mozaff. belongs to Apiaceae family is an endemic species distributed in the west of Iran. The aim of this study was to investigate the antioxidant activity and acetylcholinestrase (AchE) inhibition of the crude extract, fractions and isolated compounds from methanolic fraction of L. avicenniae. Five compounds were detected from methanol fraction, three phenolic compounds as p-coumric acid, caffeic acid, salicylic acid and two flavonoids as quercetin and astragalin. These structures were identified by spectroscopic techniques such as 1H-NMR, 13C-NMR and UV. Antioxidant activity was evaluated by the free radical scavenging assay using 2,2-diphenyl-1-picryl- hydrazyl (DPPH) method. Ellman colorimetric method was used to determine acetylcholinestrase (AChE) inhibition. In the DPPH assay, Quercetin exerted the highest antioxidant activity (IC50=10.24±1.3 µg/ml). Caffeic acid inhibited AChE with IC50 of 12.06±2.01µg/ml which were comparable to Galanthamine as positive control (IC50=62.44±2.2µg/ml). In conclusion methanol extract of L. avicenniae contains bioactive components with antioxidant and AchE inhibitory effects.
similar resources
comparison of catalytic activity of heteropoly compounds in the synthesis of bis(indolyl)alkanes.
heteropoly acids (hpa) and their salts have advantages as catalysts which make them both economically and environmentally attractive, strong br?nsted acidity, exhibiting fast reversible multi-electron redox transformations under rather mild conditions, very high solubility in polar solvents, fairly high thermal stability in the solid states, and efficient oxidizing ability, so that they are imp...
15 صفحه اولthe effect of traffic density on the accident externality from driving the case study of tehran
در این پژوهش به بررسی اثر افزایش ترافیک بر روی تعداد تصادفات پرداخته شده است. به این منظور 30 تقاطع در شهر تهران بطور تصادفی انتخاب گردید و تعداد تصادفات ماهیانه در این تقاطعات در طول سالهای 89-90 از سازمان کنترل ترافیک شهر تهران استخراج گردید و با استفاده از مدل داده های تابلویی و نرم افزار eviews مدل خطی و درجه دوم تخمین زده شد و در نهایت این نتیجه حاصل شد که تقاطعات پر ترافیک تر تعداد تصادفا...
15 صفحه اولthe role of russia in transmission of energy from central asia and caucuses to european union
پس ازفروپاشی شوروی،رشد منابع نفت و گاز، آسیای میانه و قفقاز را در یک بازی ژئوپلتیکی انرژی قرار داده است. با در نظر گرفتن این منابع هیدروکربنی، این منطقه به یک میدانجنگ و رقابت تجاری برای بازی های ژئوپلتیکی قدرت های بزرگ جهانی تبدیل شده است. روسیه منطقه را به عنوان حیات خلوت خود تلقی نموده و علاقمند به حفظ حضورش می باشد تا همانند گذشته گاز طبیعی را به وسیله خط لوله مرکزی دریافت و به عنوان یک واس...
15 صفحه اولAntidermatophytic and Toxicological Evaluations of Dichloromethane-Methanol Extract, Fractions and Compounds Isolated from Coula edulis
Background: Coula edulis Bail (Olacaceae), is an evergreen tree growing to a height of 25-38 m. This study aimed at evaluating the antidermatophytic and toxicological properties of the stem bark of C. edulis extract as well as fractions and compounds isolated from it. Methods: The plant extract was prepared by maceration in CH2Cl2-MeOH (1:1 v/v). The fractionation of this extract was do...
full textElucidation of compounds from toxic fraction of Heracleum persicum extract
Background and objectives: Heracleum persicum (Golpar)is a native medicinal plant of Iran which belongs to Apiaceae family. The fruits of the plant have been used as spice for flavoring. They have also showed carminative, antioxidant, anticonvulsant, analgesic, anti-inflammatory, immunomodulatory and cytotoxic properties. In this study, toxicity of different fractions ...
full textMy Resources
Journal title
volume 17 issue 4
pages 1386- 1391
publication date 2018-10-01
By following a journal you will be notified via email when a new issue of this journal is published.
Keywords
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023