Analgesic effects of gabapentin and ibuprofen on the pain in post therapy of root canal; a randomized double-blind clinical trial

Authors

  • Abbas Mesgarani ,Dental Materials Research Center, Department of Endodontics, Faculty of Dentistry, Babol University of Medical Sciences, Babol-Iran.
  • Ali Akbar Moghadamnia ,Department of Pharmacology and Physiology, Faculty of Medicine, Babol University of Medical Sciences, Babol-Iran.
  • Maryam Ehsani ,Dental Materials Research Center, Department of Endodontics, Faculty of Dentistry, Babol University of Medical Sciences, Babol-Iran.
  • Mona Mahyar ,Fculty of Dentistry, Babol University of Medical Sciences, Babol-Iran.
  • Sina Mirzaeerad ,Department of Endodontics, Faculty of Dentistry, Babol University of Medical Sciences, Babol-Iran.
Abstract:

&nbsp;Introduction: Inhibiting the pain which affects both the patients and dentists is an important factor during treating dental patients. The aim of this study was to assess the analgesic effect of two medications ibuprofen and gabapentin on the post-endodontic-therapy pain. Methods: Forty patients who need root canal therapy with Visual Analog Scale (VAS)>40, participated in this double-blind randomized clinical trial study and randomly divided into two groups. The ibuprofen group received 800 mg ibuprofen 1 hour before the treatment and 400 mg at 6, 12 and 24 hours after the treatment procedure, and the other group received 600 mg gabapentin 1 hour before the treatment and 300 mg at 6, 12 and 24 hours after treatment. Patients recorded the intensity of pain via VAS before treatment and every hour for the first 6 h after taking the medication and then every 6 h thereafter for a total of the 48-hour period. (Two tablets of acetaminophen codeine (325mg/20mg) were given to the patients as a rescue dose. Results: The analgesic effect of gabapentin was significantly higher than ibuprofen in 12h (p=0.035), 24h (p<0.001), and 48 h (p=0.012) after analgesic intake. It has been also shown that both medicines had analgesic effect significantly. (p<0.0001) Conclusions: Gabapentin had greater analgesic effects on the sample group from 12 h until 48h after taking in comparison with ibuprofen so it seems that it could be an appropriate option for postoperative pain inhibition.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Gabapentin Effect on Pain Associated with Heroin Withdrawal in Iranian Crack: a Randomized Double-blind Clinical Trial

Gabapentin seems to be a safe and well tolerated medication for treating heroine dependence. This study examined the efficacy of gabapentin for relieving withdrawal-related pain due to heroin use.Sixty men were recruited from an inpatient psychiatric ward of Fatemieh hospital in Semnan and randomized to receive either placebo (n = 30) or gabapentin (1800 mg/day) (n = 30) for 7 days. Subjective ...

full text

Gabapentin Effect on Pain Associated with Heroin Withdrawal in Iranian Crack: a Randomized Double-blind Clinical Trial

Gabapentin seems to be a safe and well tolerated medication for treating heroine dependence. This study examined the efficacy of gabapentin for relieving withdrawal-related pain due to heroin use.Sixty men were recruited from an inpatient psychiatric ward of Fatemieh hospital in Semnan and randomized to receive either placebo (n = 30) or gabapentin (1800 mg/day) (n = 30) for 7 days. Subjective ...

full text

Effect of acupuncture on the pain of patients with acute low back pain: A randomized double-blind clinical trial study

Introduction: Low back pain is one of the most common causes of daily activity limitation and functional disabilities that affect a large number of people in the community. Due to the ineffectiveness of oral analgesics in relieving this type of pain and the need for their long-term use, which has its own side effects, the present study investigated the supplementary effect of acupuncture on pai...

full text

Effectiveness of Prophylactic Celebrex and Celecoxib Administration for Controlling Post-endodontic Pain: A Randomized Double-blind Clinical Trial

Introduction Pain control following root canal therapy is a challenging issue in dentistry. This double-blind study aimed to compare the effectiveness of Celebrex and celecoxib used to control post-endodontic pain. Material and Methods In this randomized, double-blind study, 43 patients with symptomatic teeth were selected. The subjects gave their consent for a prophylactic oral administrati...

full text

The Effect of Hydroxychloroquine on Symptoms of Knee Osteoarthritis: A Double-Blind Randomized Controlled Clinical Trial

Background: Osteoarthritis is a degenerative joint disorder of articular cartilage and is the most common type of arthritis in the elderly. There are only a few reports regarding the use of Hydroxychloroquine in the treatment of osteoarthritis. Methods: To investigate the effects of Hydroxychloroquine on the symptoms of mild to moderate knee osteoarthritis (Kellgren and Lawrence grade II and II...

full text

on translation of politeness strategies in dialogues involving female characters in translations and retranslations of novels translated before and after the islamic revolution of iran and their effects on the image of women: a polysystem theory approach

abstract reception environment has considerable effects on accepting a translation. as the expectations of a target culture and its values and needs change throughout history, its criteria for accepting a translation or rejecting it will change accordingly (gentzler, 2001). the expectations of iran, as the reception environment in the present study, have changed after the islamic revolution. i...

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 3  issue None

pages  8- 13

publication date 2014-09

By following a journal you will be notified via email when a new issue of this journal is published.

Keywords

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023