Analgesic effects of alpha-pinene on pain models of writing and plantar tests in rats

 Background: The aim of this study was to evaluate the analgesic effects of Alpha Pinene in writing and plantar pain tests in rats. Methods: This study was performed on male Wistar rats. Group 1: Normal saline was administered intraperitoneally (IP). Group 2: Diclofenac sodium at a dose of 5 mg/kg was administered (IP). Group 3: Alpha Pinene was administered (IP) at a dose of 0.1 mg/kg. Group 4: Alpha Pinene was administered (IP) at a dose of 5 mg/kg. Group 5: Alpha Pinene was administered intraperitoneally at a dose of 10 mg/kg. Then writing and plantar tests (five groups for each test) were performed. Results: The results showed that in the writing test, the number of abdominal twists in the groups that received alpha pinene was significantly lower than the control group (P<0.05). Also, in the writing test, diclofenac sodium 5 mg decreased pain intensity compared to the control group (P<0.05). In the plantar test, the pain intensity in the groups that received alpha pinene 5 mg/kg and diclofenac sodium 5 mg was significantly lower than the control group (P<0.05). Conclusion: Alpha Pinene in doses of 5 and 10 mg/kg can reduce the severity in the visceral pain model of writing test. Also, at 30 and 60 minutes in the plantar test Alpha Pinene at a dose of 5 mg/kg, like diclofenac sodium (at a dose of 5 mg) can reduce pain.