سنتز مشتقات جدید 2 و 3-دی آریل کینوکسالین و کینوکسالین اکسید با پتانسیل اثرات ضد سرطانی و ضد میکروبی

Background and purpose: Quinoxaline derivatives are standing interest of people who work on anti-cancer drugs. There are many reports about using these agents as DNA cleaving, transglutaminase 2 inhibitor, topoisomerase II inhibitor and tumor antibiotic. Other drugs used in treatment of tuberculosis such as isoniazid, pyrazinamide and rifampin have similar structures to quinoxaline and quinoxaline 1, 4-di-N-oxide derivatives. This study aimed to prepare 2, 3 diaryl quinoxaline and quinoxaline oxide as potential anticancer and antituberculosis compounds. Materials and methods: The first step involved the conversion of benzaldehyde to benzoine in the presence of sodium cyanide. Direct oxidation of related benzoines to 1,2-diketon compounds were performed using nitric acid which then underwent a nucleophilic attack by phenylenediamine that led to quinoxaline derivatives in high yield. Subsequently, anhydride acetic acid and hydrogen peroxide was employed for the oxidation quinoxaline derivatives to desired 1,4- N-oxide quinoxaline. Results: The 2,3-diarylquinoxaline and quinoxaline oxide derivatives were synthesized and their chemical structures were confirmed using1H-NMR and IR spectroscopy. Conclusion: In this study an efficient method was developed for the preparation of novel derivatives of quinoxaline and 1,4- N-oxide quinoxaline as potential anticancer and antituberculosis agents.