خواص ضد اکسیدان برون سلولی عصاره برخی اسفنج های دریایی سواحل چابهار

Background: Free radicals cause different diseases. Today&rsquo;s finding of natural antioxidants is an interest. Marine sponges will be an important drug source in future. In this study the antioxidative effects of some marine sponges from Chabahar Tidal Seashores investigated. Methods: After gathering and recognition of sponges, distilled water and methanol 96% used as solvent for extraction. Free radical scavenging activity, metal chelating activity and reduction power were measured after total phenolic content assayed in the extracts and compared with the standards. Results: water extracts of Dysideidae, Halichondriidae &nbsp;and callyspongia showed more free radical scavenging activity in compare with alcoholic extract (p<0.05). In Clionaidae sponge it was vice versa.&nbsp; All sponge extracts showed high metal chelating activity and this actitivity in Dysideidae and callyspongia was the same with EDTA. Reduction power in all samples was good and water extract showed higher reduction than alcoholic extracts. Maximum phenolic content was belonging to Dysideidae and the minimum to Clionaidae sponges. Conclusion: Results showed sponges extracts in this study had a good content of antioxidative activity especially in metal chelating activity and with more clinical study we could reach to a way for drug delivery from the marine environment.