تأثیر سه ماه تمرین هوازی بر مسیر پیام رسانی Wnt عضله‌ اسکلتی موش‌های صحرایی نر

Background: Atrophy in skeletal muscle plays an important role in disease-related tissue dysfunction such as sarcopenia. The Wnt-signaling pathway has been shown to be critical for skeletal muscle development. Current evidence suggests that exercise trainings may alter hypertrophy-related signaling in skeletal muscle. Therefore, the purpose of this study was investigating the effect of three months aerobic training on Wnt-signaling pathway in skeletal muscle of male rats. Methods: This study was conducted as a two-group experimental design and sixteen 3-month-old male rats were selected and randomly divided into two groups of aerobic training (n=8) and control (n=8). Rats in trained group participated in the aerobic training program for three months (75-80% ). 48 hours after the last training session, the soleus muscle of rats were extracted and &beta;-catenin and glycogen synthase kinase-3&beta; mRNA evaluated by Real Time-PCR. Independent t-test was applied for statistical analysis of the data (P<0.05). Results: &beta;-catenin gene expression of trained group (1.11&plusmn;0.17) was no-significantly lower than the control group (1.60&plusmn;0.99) (30%, P=0.154). However, glycogen synthase kinase-3&beta; gene expression of trained group (10.36&plusmn;3.51) was significantly higher than the control group (1.99&plusmn;1.2) (420%, P=0.001). Conclusion: In general, it seems that a three months aerobic training was effective in increasing glycogen synthase kinase-3&beta; gene expression in skeletal muscle. This may be associated with an increased risk of muscle atrophy. However, more researches are needed to identify effects of different exercise trainings on Wnt-signaling pathway.