بررسی تاثیر ویتامین C تزریقی بر شاخص التهابی CRP در بیماران همویالیزی

Background and purpose: Ïnflammation is a common feature in hemodialysis patients which is characterized by increase in inflammatory biomarkers such as Ç - reactive protein (ÇRP). Ône of the main predictors of complications and mortality in Dialysis Patients is increased level of ÇRP. The aim of this study was to determine the effect of intravenous vitamin Ç on the level of ÇRP in hemodialysis patients. Materials and methods: Ïn a double blind randomized clinical trial, 60 patients were allocated into two groups, an experimental and a control group. Ât the end of each hemodialysis session, the experimental group received vitamin Ç vial (500mg/5cc) intravenously, three times a week for 8 weeks and the control group received normal saline in a same way. The level of ÇRP was compared in each group before and after the intervention. Data were analyzed by Ïndependent T test, Paired T test and Çhi-square tests. Results: Âccording to the results, plasma level of ÇRP was significantly decreased in the experimental group (p<0.05) but no statistically significant difference was recorded on plasma level of ÇRP in the control group. Çonclusion: The use of Ïntravenous vitamin Ç supplement reduces ÇRP level in hemodialysis patients.