اپیدمیولوژی دیس‌پپسی در جمعیت عمومی شهر نهاوند، ایران

Background: The prevalence and demographic features of dyspepsia are unknown in Iran. Thus, the present study was conducted to determine the epidemiology of dyspepsia in Nahavand. Materials and methods: From 5 urban regions in Nahavand (with more than 61000 population), 1518 subjects (mean age ± standard deviation 36.4±9.7 years, 865 females) were recruited through a systematic random sampling. Patients were questioned about dyspeptic symptoms, presence of any chronic disease, frequently used medications, previous operations and cigarette smoking in the previous 12 months. Dyspepsia was defined as the presence of following symptoms pyrosis, upper abdominal pain, bloating, nausea, vomiting, or early satiety, and abdominal fullness, for at least one month during the previous six months. Data obtained through face-to-face interview was documented on structured questionnaires. The association between various demographic and lifestyle factors with dyspepsia was quantified by odds ratios (ORs) using logistic regression. Results: 358 subjects (23.6%) had dyspepsia. Abdominal fullness (n=165) and abdominal pain (175) were the most common symptoms. More than half (n=183, 55%) had symptoms suggestive of dysmotility-like dyspepsia mixed type dyspepsia was the next most common (n=126 38%). Dyspepsia was more prevalent in subjects exposed to tobacco smoke, but it was not associated with alcohol abuse. Use of nonsteroidal anti-inflammatory drugs (OR=1.92, 95%CI=1.49-2.49, p<0.001), current smoking (OR= 2.45, 95%CI=1.45-4.07, p<0.001), and lower education level (OR=1.73, 95%CI=1.21-2.47, p<0.001) were associated with dyspepsia. 258 subjects with dyspepsia (60.7%) had received treatment with H2 blockers or proton pump antagonists, 7.7% had undergone previous endoscopy. Conclusion: Dyspepsia is reported by almost one-third of the population in Nahavand. Sixty percent of these cases receive treatment however endoscopy is performed in a small number of patients.