ارزیابی اثر نانوذرات داستیل کیتین بر میزان بیان ژن VEGF در مدل متاستاتیک سرطان سینه

Background and purpose: Breast cancer is one of the leading causes of death in women around the world. Conventional treatments use cytotoxic drugs which have high levels of side effects. Today, researchers are more interested in developing novel drugs that have lower side effects and maximum efficiency. Deacetylchitin is a biodegradable and biocompatible polymer. The goal of this research was to evaluate the effect of Deacetylchitin on VEGF gene expression in metastatic breast cancer model. Materials and methods: In this study, Deacetyl chitin nanoparticle was synthesized. The size and zeta potential of nanoparticle was determined. Mouse models of breast cancer were treated by Deacetyl chitin. Expression of VEGF genes was evaluated using real time PCR. Results: Deacetyl chitin nanoparticle size was 210 nm. Statistical analysis showed that Deacetyl chitin reduced the expression of VEGF gene (P<0.05) compared with that in the control group. Conclusion: Deacetyl chitin reduced the expression of metastatic genes on mouse models of breast cancer, therefore, it could be suggested as a new tool for future therapeutic strategies aimed in cancer therapy. &nbsp;