Solitary asymptomatic nodule on the leg.

نویسندگان

  • Ana Almodovar-Real
  • José Aneiros-Fernandez
  • Miguel A Diaz-Martinez
  • Ramón Naranjo-Sintes
چکیده

© 2016 Indian Journal of Dermatology, Venereology, and Leprology | Published by Wolters Kluwer Medknow A 58-year-old man presented with an asymptomatic skin nodule on the left leg for several months. Physical examination showed a well-defined, erythematous nodule (2 cm × 1.5 cm) with a lobulated surface [Figure 1]. Differential diagnoses of squamous cell carcinoma, basal cell carcinoma and cutaneous lymphoma were considered. An excisional biopsy was performed. Histopathology showed pseudoepitheliomatous hyperplasia [Figure 2]. There was a dense, irregular, lymphoid infiltrate with admixture of neutrophils, eosinophils and large, atypical Reed-Sternberg-like cells in the dermis [Figure 3]. Immunohistochemical analysis revealed strong positivity for CD30 [Figure 4a]. Tumor cells were also positive for the cytotoxic marker T-cell intracellular antigen-1 [Figure 4b], CD3, CD7 and CD4 [Figure 4c]. On the other hand, AE1-AE3, CD8, CD56, CD20, ALK-1, CD5, CD15 and CD25 were all negative. Routine investigations and positron emission tomography-computed tomography study were normal. There was no recurrence after 1 year of follow-up.

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عنوان ژورنال:
  • Indian journal of dermatology, venereology and leprology

دوره 82 1  شماره 

صفحات  -

تاریخ انتشار 2016