Motor nerve regulates muscle extracellular matrix proteoglycan expression.
نویسندگان
چکیده
Denervation of rat leg muscles caused a 2-3-fold increase in 35S-sulfate and 3H-glucosamine incorporation into proteoglycans of the muscle extracellular matrix. The size of the proteoglycans and the glycosaminoglycan chain length and degree of sulfation were unchanged. Because the rate of degradation of proteoglycans was also unchanged by denervation, we infer that denervation increases proteoglycan synthesis. Muscle reinnervation restored the original rate of synthesis of proteoglycans. Paralysis of innervated muscle caused increased incorporation of sulfate comparable to that seen in denervation. Thus motor nerve activity appears to regulate the level of proteoglycans in the muscle extracellular matrix.
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ورودعنوان ژورنال:
- The Journal of neuroscience : the official journal of the Society for Neuroscience
دوره 10 11 شماره
صفحات -
تاریخ انتشار 1990